Effects of Kangfuxin liquid combined with Omeprazole in treatment of patients with gastrointestinal ulcer
Objective:To observe effects of Kangfuxin liquid combined with Omeprazole in treatment of patients with gastrointestinal ulcer.Methods:The clinical data of 70 patients with gastrointestinal ulcer admitted to this hospital from June 2021 to October 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,35 cases in each group.The control group was treated with Omeprazole,while the observation group was treated with Kangfuxin liquid on the basis of that of the control group.The clinical efficacy,the clinical symptom scores,the intestinal mucosal barrier function indexes[diamine oxidase(DAO),D-lactic acid(D-LA),endothelin(ET)]levels,the inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.14%(34/35),which was higher than 77.14%(27/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as abdominal pain,abdominal distension and acid reflux in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of DAO,ET and D-LA in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-6 and TNF-α in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Kangfuxin liquid combined with Omeprazole in the treatment of the patients with gastrointestinal ulcer can improve the total effective rate of treatment,and reduce the clinical symptom scores,the intestinal mucosal barrier function index levels and the inflammatory factor index levels.Moreover,it is superior to simple Omeprazole treatment.
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