摘要
目的:观察康复新液联合奥美拉唑治疗消化道溃疡患者的效果.方法:回顾性分析 2021 年 6 月至 2023 年 10 月该院收治的 70 例消化道溃疡患者的临床资料,根据治疗方法不同将其分为对照组和观察组各 35 例.对照组给予奥美拉唑治疗,观察组在对照组基础上联合康复新液治疗.比较两组临床疗效,治疗前后临床症状评分、肠黏膜屏障功能指标[二胺氧化酶(DAO)、D-乳酸(D-LA)、内皮素(ET)]水平、炎性因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率.结果:观察组治疗总有效率 97.14%(34/35),高于对照组的 77.14%(27/35),差异有统计学意义(P<0.05);治疗后,两组腹痛、腹胀、反酸等临床症状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组DAO、ET、D-LA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组hs-CRP、IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:康复新液联合奥美拉唑治疗消化道溃疡患者可提高治疗总有效率,以及降低临床症状评分、肠黏膜屏障功能指标水平和炎性因子水平的效果优于单纯奥美拉唑治疗效果.
Abstract
Objective:To observe effects of Kangfuxin liquid combined with Omeprazole in treatment of patients with gastrointestinal ulcer.Methods:The clinical data of 70 patients with gastrointestinal ulcer admitted to this hospital from June 2021 to October 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,35 cases in each group.The control group was treated with Omeprazole,while the observation group was treated with Kangfuxin liquid on the basis of that of the control group.The clinical efficacy,the clinical symptom scores,the intestinal mucosal barrier function indexes[diamine oxidase(DAO),D-lactic acid(D-LA),endothelin(ET)]levels,the inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.14%(34/35),which was higher than 77.14%(27/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as abdominal pain,abdominal distension and acid reflux in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of DAO,ET and D-LA in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-6 and TNF-α in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Kangfuxin liquid combined with Omeprazole in the treatment of the patients with gastrointestinal ulcer can improve the total effective rate of treatment,and reduce the clinical symptom scores,the intestinal mucosal barrier function index levels and the inflammatory factor index levels.Moreover,it is superior to simple Omeprazole treatment.
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