Comparison of effects of peritoneal dialysis and high-flux hemodialysis in treatment of patients with end-stage renal disease
Objective:To compare effects of peritoneal dialysis and high-flux hemodialysis in treatment of patients with end-stage renal disease.Methods:The clinical data of 70 patients with end-stage renal disease admitted to this hospital from January 2021 to June 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,35 cases in each group.The control group was treated with high-flux hemodialysis,while the observation group was treated with peritoneal dialysis.The levels of renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr),glomerular filtration rate(GFR),β2-microglobulin(β2-MG)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hyper-sensitive C-reactive protein(hs-CRP)]and T cell subsets(CD4+,CD3+,CD8+,CD4+/CD8+)before and after the treatment,and the incidence of complications were compared between the two groups before and after the treatment.Results:After the treatment,the levels of BUN,Scr and β2-MG in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the GFR levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-6 and hs-CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4+,CD3+and CD4+/CD8+in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of CD8+in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Peritoneal dialysis in the treatment of the patients with end-stage renal disease can improve the levels of renal function indexes and T cell subsets,and reduce the levels of inflammatory factors.Moreover,it is superior to high-flux hemodialysis treatment.
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