Comparison of effects of drug-coated balloon and drug-eluting stent in interventional therapy for patients with lower extremity arteriosclerosis obliterans
Objective:To compare application effect of drug-coated balloon(DCB)and drug-eluting stent in patients with lower extremity arteriosclerosis obliterans(ASO).Methods:A prospective study was conducted on 82 patients with lower extremity ASO admitted to this hospital from August 2020 to August 2022.According to the random number table method,they were divided into study group and control group,41 cases in each group.Percutaneous transluminal angioplasty(PTA)was performed in both groups.The control group was treated with Rapamycin eluting stent,while the study group was treated with DCB.The short-term efficacy,the levels of vascular function indexes(target artery stenosis rate and ankle brachial index)before and after the surgery,the incidence of complications,the incidence of target artery restenosis,and the revascularization 1 year after the surgery were compared between the two groups.Results:The total effective rate of the study group was 95.12%(39/41),and that of the control group was 87.80%(36/41);there was no significant difference between the two groups(P>0.05).One month after the surgery,the target artery stenosis rates of the two groups were lower than those before the surgery,the ankle brachial index levels were higher than those before the surgery,and the differences were statistically significant(P<0.05);however,there were no significant differences between the two groups(P>0.05).One year after the surgery,the incidence of target artery restenosis and revascularization in the study group were 14.63%and 7.32%,respectively,which were lower than 53.66%and 36.59%in the control group,the differences were statistically significant(P<0.05).Conclusions:The short-term efficacy and the incidence of complications of DCB in the treatment of the patients with lower extremity ASO are comparable to those of drug-eluting stents.Both of them can effectively restore the inner diameter of blood vessels and the ankle brachial index,but DCB can improve the long-term efficacy and reduce the incidence of target artery restenosis and revascularization 1 year after the surgery.
Lower extremityArteriosclerosis obliteransDrug-coated balloonDrug-eluting stentInterventional therapyAnkle brachial index
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