Comparison of effects of Mifepristone and Gestrinone in treatment of patients with endometriosis surgery
Objective:To compare effects of Mifepristone and Gestrinone in treatment of patients with endometriosis surgery.Methods:A prospective study was conducted on 120 patients with endometriosis admitted to the hospital from May 2021 to May 2022.According to the random number table method,they were divided into control group and observation group,60 cases in each group.Both groups underwent laparoscopic surgery to remove the lesion.After the surgery,the control group was treated with Gestrinone capsules orally,while the observation group was treated with Mifepristone tablets orally.The clinical efficacy,the ovarian function indexes(luteinizing hormone,estradiol,follicle stimulating hormone,prolactin,progesterone)levels,the disease-related indexes[caspase-3,suppressor of cytokine signaling-3(SOCS-3),vascular endothelial growth factor(VEGF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(58/60),which was higher than 78.33%(47/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of luteinizing hormone in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of estradiol,follicle stimulating hormone,prolactin and progesterone in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).After the treatment,the levels of serum caspase-3 and SOCS-3 in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the serum VEGF levels of the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Mifepristone in the treatment of the patients with endometriosis surgery can improve the total effective rate of treatment,improve the levels of ovarian function indexes and disease-related indexes,and reduce the incidence of adverse reactions.Moreover,it is superior to simple Gestrinone treatment.
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