Effects of Sacubitril valsartan sodium in treatment of uremic hemodialysis patients with heart failure
Objective:To observe effects of Sacubitril valsartan sodium in treatment of uremic hemodialysis patients with heart failure.Methods:A prospective study was conducted on 76 uremia hemodialysis patients with heart failure admitted to this hospital from June 2020 to March 2023.According to the random number table method,they were divided into control group and observation group,38 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with Sacubitril valsartan sodium on the basis of that of the control group.The clinical efficacy,the cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),N-terminal pro-brain natriuretic peptide(NT-pro BNP)]levels and the renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr),homocysteine(Hcy)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.74%(36/38),which was higher than 78.95%(30/38)of the control group,and the difference was statistically significant(P＜0.05).After the treatment,the levels of LVESD,LVESV,NT-proBNP,Scr,BUN and Hcy in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions:On the basis of the conventional treatment,Sacubitril valsartan sodium in the treatment of the uremic hemodialysis patients with heart failure can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of renal function indexes.Moreover,it is superior to single conventional treatment.
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