Effects of Hemocoagulase bothrops atrox for injection combined with Omeprazole in treatment of elderly patients with acute upper digestive tract hemorrhage
Objective:To observe effects of Hemocoagulase bothrops atrox for injection combined with Omeprazole in treatment of elderly patients with acute upper digestive tract hemorrhage.Methods:A prospective study was conducted on 60 elderly patients with acute upper digestive tract hemorrhage admitted to this hospital from January 2022 to February 2024.According to the random number table method,they were divided into observation group and control group,30 cases in each group.The control group was treated with Omeprazole sodium for injection,while the observation group was treated with Hemocoagulase bothrops atrox for injection on the basis of that of the control group.The bleeding stop time,the abdominal pain disappearance time,the hospitalization time,the coagulation function index(prothrombin time,activated partial thromboplastin time,fibrinogen)levels,the stress index(serum cortisol,norepinephrine)levels,and the incidence of adverse reactions were compared between the two groups.Results:The bleeding stop time,the abdominal pain disappearance time and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).After the treatment,the prothrombin time and the activated partial thromboplastin time in the two groups were shorter than those before the treatment,and those in the observation group were shorter than those in the control group;the levels of fibrinogen in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P＜0.05).After the treatment,the levels of stress indexes such as serum cortisol and norepinephrine in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions:Hemocoagulase bothrops atrox for injection combined with Omeprazole in the treatment of the elderly patients with acute upper digestive tract hemorrhage can shorten the bleeding stop time,the abdominal pain disappearance time and the hospitalization time,improve the levels of coagulation function indexes,and reduce the levels of stress indexes.Moreover,it is superior to simple Omeprazole treatment.
Hemocoagulase bothrops atrox for injectionOmeprazoleElderlyAcute upper digestive tract hemorrhageCoagulation functionStress
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