首页|拉贝洛尔联合硝苯地平治疗妊娠期高血压患者的效果

拉贝洛尔联合硝苯地平治疗妊娠期高血压患者的效果

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目的:观察拉贝洛尔联合硝苯地平治疗妊娠期高血压患者的效果.方法:回顾性分析 2021 年 4 月至 2023 年 4 月该院收治的 94 例妊娠期高血压患者的临床资料,根据治疗方法不同分为对照组(n=47)、观察组(n=47).对照组采用硝苯地平片治疗,观察组在对照组基础上联合盐酸拉贝洛尔片治疗,比较两组临床疗效、血压[舒张压(DBP)、平均动脉压(MAP)、收缩压(SBP)]水平、血栓弹力图(TEG)指标[最大切角(α角)、凝血因子激活时间(R)、最大血块强度(MA)、血块形成速率(K)]水平和不良母婴结局发生率.结果:观察组治疗总有效率为 91.49%,明显高于对照组的 74.47%,差异有统计学意义(P<0.05);治疗后,两组DBP、MAP、SBP水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组R、K水平高于治疗前,且观察组高于对照组,两组α角、MA水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组不良母婴结局发生率为 10.65%,低于对照组的 27.66%,差异有统计学意义(P<0.05).结论:拉贝洛尔联合硝苯地平治疗妊娠期高血压患者可提高治疗总有效率,改善TEG指标水平,降低DBP、MAP、SBP水平以及不良母婴结局发生率,效果优于单纯硝苯地平治疗.
Effects of Labetalol combined with Nifedipine in treatment of patients with gestational hypertension
Objective:To observe effects of Labetalol combined with Nifedipine in treatment of patients with gestational hypertension.Methods:The clinical data of 94 patients with gestational hypertension admitted to this hospital from April 2021 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=47)and observation group(n=47).The control group was treated with Nifedipine tablets,while the observation group was treated with Labetalol hydrochloride tablets on the basis of that of the control group.The total effective rate of treatment,the blood pressure[diastolic blood pressure(DBP),mean arterial pressure(MAP),systolic blood pressure(SBP)],the thrombelastogram(TEG)index[maximum tangential angle(α angle),coagulation factor activation time(R),maximal amplitude(MA),blood clot formation rate(K)]levels,and the incidence of adverse maternal and infant outcomes were compared between the two groups.Results:The total effective rate of the observation group was 91.49%,which was significantly higher than 74.47%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of DBP,MAP and SBP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of R and K in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of α angle and MA in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse maternal and infant outcomes in the observation group was 10.65%,which was lower than 27.66%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Labetalol combined with Nifedipine in the treatment of the patients with gestational hypertension can improve the total effective rate of treatment,improve the levels of TEG indexes,and reduce the levels of DBP,MAP and SBP and the incidence of adverse maternal and infant.T Moreover,it is superior to simple Nifedipine treatment.

Gestational hypertensionLabetalolNifedipineBlood pressureThrombelastogramMaternal and infant outcome

车雪萍、梅艳慧、吴楠楠

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郑州圣玛妇产医院药剂科,河南 郑州 450000

妊娠期高血压 拉贝洛尔 硝苯地平 血压 血栓弹力图 母婴结局

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(17)