Effects of low molecular weight Heparin calcium combined with Magnesium sulfate in treatment of patients with severe preeclampsia
Objective:To observe effects of low molecular weight Heparin calcium combined with Magnesium sulfate in treatment of patients with severe preeclampsia.Methods:A prospective study was conducted on 88 patients with severe preeclampsia admitted to the hospital from January 2020 to February 2023.They were divided into control group(n=44)and observation group(n=44)by using the random number table method.The control group was treated with Magnesium sulfate,while the observation group was treated with low molecular weight Heparin calcium injection on the basis of that of the control group.The clinical efficacy,the levels of hemorheology indexes[plasma viscosity(PV),fibrinogen(FIB),erythrocyte sedimentation rate(ESR),hematocrit(HCT)]before and after the treatment,the incidence of adverse pregnancy outcomes,and the incidence of adverse neonatal outcomes were compared between the two groups.Results:The total effective rate of the observation group was 95.45%(42/44),which was higher than 75.00%(33/44)of the control group,and the difference was statistically significant(P＜0.05).After the treatment,the levels of PV,FIB,ESR and HCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The incidences of cesarean section,premature delivery,placental abruption and postpartum hemorrhage in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Further,the incidence of fetal distress and neonatal asphyxia in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusions:Low molecular weight Heparin calcium combined with Magnesium sulfate in the treatment of the patients with severe preeclampsia can improve the total effective rate of treatment and reduce the levels of hemorheology indexes,the incidence of adverse pregnancy outcomes and the incidence of adverse neonatal outcomes.Moreover,it is superior to simple Magnesium sulfate treatment.
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