Effects of interferon α suppository combined with Carbon dioxide laser in treatment of patients with condyloma acuminatum
Objective:To observe effects of interferon α suppository combined with Carbon dioxide laser in treatment of patients with condyloma acuminatum.Methods:A prospective study was conducted on 100 patients with condyloma acuminatum admitted to this hospital from May 2021 to May 2023.According to the random number table method,they were divided into study group and control group,50 cases in each group.The control group was treated with Carbon dioxide laser,while the study group was treated with Interferon α suppository on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)]and T cell subsets indexes(CD3+,CD4+,CD8+)before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.00%,which was higher than 84.00%in the control group,and the difference was statistically significant(P＜0.05).After the treatment,the levels of PCT,IL-6 and CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of CD3+and CD4+in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of CD8+in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The recurrence rate of the study group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusions:Interferon α suppository combined with Carbon dioxide laser in the treatment of the patients with condyloma acuminatum can improve the clinical efficacy,improve the levels of T cell subsets and reduce the levels of inflammatory factors and the recurrence rate.Moreover,it is superior to simple Carbon dioxide laser therapy.
万方数据
维普
