Effects of Sevoflurane inhalation combined with intravenous general anesthesia in patients undergoing radical surgery for oral cancer
Objective:To observe application effects of Sevoflurane inhalation combined with intravenous general anesthesia in patients undergoing radical surgery for oral cancer.Methods:A prospective study was conducted on 80 patients with oral cancer admitted to the hospital from July 2021 to July 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.Both groups were induced by intravenous anesthesia.The control group was given Propofol combined with Remifentanil for anesthesia maintenance,while the study group was given Sevoflurane combined with intravenous anesthesia for anesthesia maintenance.The levels of hemodynamic indexes at different time during the operation,the dosage of intravenous anesthetics(Propofol and Remifentanil)during the operation,the levels of recovery period indexes(recovery time,spontaneous breathing recovery time and extubation time)and stress indexes[cortisol(Cor),norepinephrine(NE)]before and after the surgery,and the incidence of adverse reactions were compared between the two groups.Results:The levels of mean arterial pressure and heart rate of the two groups decreased after anesthesia induction,and increased during intubation and extubation.However,the mean arterial pressure and heart rate during intubation and extubation in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The dosage of Propofol and Remifentanil in the study group was less than that in the control group,and the difference was statistically significant(P＜0.05).The recovery time,the spontaneous breathing recovery time and the extubation time of the study group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).1 day after the surgery,the levels of serum Cor and NE in the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Further,the incidence of adverse reactions in the study group was 7.50%(3/40),which was lower than 25.00%(10/40)in the control group,and the difference was statistically significant(P＜0.05).Conclusions:Compared with total intravenous anesthesia,Sevoflurane inhalation combined with intravenous general anesthesia is effective in the patients undergoing radical surgery for oral cancer.It is beneficial to maintain the hemodynamic stability,inhibit the stress response,reduce the dosage of intravenous anesthetics,accelerate the postoperative recovery,and has high safety.
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