Efficiency of combined detection of hyaluronic acid,retinol binding protein and glycosylated hemoglobin levels in diagnosis of diabetic nephropathy
Objective:To analyze efficiency of combined detection of hyaluronic acid(HA),retinol-binding protein(RBP)and glycosylated hemoglobin(HbA1c)levels in diagnosis of diabetic nephropathy.Methods:A total of 90 patients with diabetic nephropathy admitted to this hospital from January 2021 to December 2023 were selected as the observation group,and 68 healthy subjects during the same period were selected as the control group.The levels of HA,RBP and HbA1c were compared between the two groups and among the patients with different clinical stages of diabetic nephropathy.The receiver operating characteristic(ROC)curve was used to analyze the efficiencies of single and combined detection of HA,RBP and HbA1c levels in the diagnosis of diabetic nephropathy.Results:The levels of HA,RBP and HbA1c in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of HA,RBP and HbA1c in the patients with stage IV diabetic nephropathy were higher than those in the patients with stage II and III,those in the patients with stage III were higher than those in the patients with stage II,and the differences were statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve of single and combined detection of HA,RBP and HbA1c levels in the diagnosis of diabetic nephropathy were 0.905,0.912,0.908 and 0.926,respectively.The efficiency of combined detection was higher than that of each single detection.Conclusions:The efficiency of combined detection of HA,RBP and HbA1c levels in the diagnosis of diabetic nephropathy is higher than that of each single detection.
万方数据
维普
