Diagnostic value of combined detection of serum CYFRA21-1,NSE and VEGF levels for lymph node metastasis in patients with lung cancer
Objective:To investigate diagnostic value of combined detection of serum cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),neuron-specific enolase(NSE)and vascular endothelial growth factor(VEGF)levels for lymph node metastasis in patients with lung cancer.Methods:The clinical data of 150 patients with lung cancer admitted to this hospital from January 2020 to December 2022 were retrospectively analyzed.According to whether lymph node metastasis occurred,they were divided into metastasis group(n=52)and non-metastasis group(n=98).The pathological type,the clinical stage and the serum levels of CYFRA21-1,NSE and VEGF were compared between the two groups.Further,the serum levels of CYFRA21-1,NSE and VEGF in the patients with different clinical stage were also compared.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of single and combined detection of serum CYFRA21-1,NSE and VEGF levels for lymph node metastasis in the patients with lung cancer.Results:The proportion of small cell carcinoma,the clinical stage and the serum CYFRA21-1,NSE and VEGF levels in the metastasis group were higher than those in the non-metastasis group;the higher the clinical stage was,the higher the levels of serum CYFRA21-1,NSE and VEGF were;and the differences were statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve of single and combined detection of serum CYFRA21-1,NSE and VEGF levels in the diagnosis of lymph node metastasis in the patients with lung cancer was 0.873,0.828,0.701 and 0.954,respectively,and the diagnostic value of combined detection was higher than that of single detection.Conclusions:The detection of the serum CYFRA21-1,NSE and VEGF levels has high diagnostic value for lymph node metastasis in the patients with lung cancer,and the diagnostic value of combined detection is higher than that of single detection.
万方数据
维普
