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余江区学龄前儿童乙肝疫苗接种后发生无(弱)免疫应答的影响因素

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目的:分析余江区学龄前儿童乙肝疫苗接种后发生无(弱)免疫应答的影响因素.方法:采用整群抽样方式,选取2023年1-10月余江区1237名学龄前儿童为研究对象,统计余江区学龄前儿童乙肝疫苗接种后免疫应答情况,采用Logistic回归分析余江区学龄前儿童接种乙肝疫苗后发生无(弱)免疫应答的影响因素.结果:余江区学龄前1237名儿童乙肝疫苗接种后发生无(弱)应答651名,占52.63%,设为发生组,应答586名,占47.37%,设为未发生组.发生组年龄大、父亲乙型肝炎病毒(HBV)携带、父亲既往有疫苗无(弱)应答史、母亲既往有疫苗无(弱)应答史、营养不佳/差等占比均高于未发生组,差异有统计学意义(P<0.05).经Logistic回归分析结果显示,年龄大、父亲HBV携带、父亲既往有疫苗无(弱)应答史、母亲既往有疫苗无(弱)应答史、营养状况不佳/差等均为影响余江区学龄前儿童乙肝疫苗接种后发生无(弱)免疫应答的危险因素(OR>1,P<0.05).结论:年龄大、父亲HBV携带、父亲既往有疫苗无(弱)应答史、母亲既往有疫苗无(弱)应答史、营养状况不佳/差等均为影响余江区学龄前儿童乙肝疫苗接种后发生无(弱)免疫应答的危险因素.
Influencing factors of no(weak)immune response after hepatitis B vaccination in preschool children in Yujiang district
Objective:To analyze influencing factors of no(weak)immune response after hepatitis B vaccination in preschool children in Yujiang district.Methods:1237 preschool children in Yujiang district from January 2023 to October 2023 were selected as the research objects by using the cluster sampling.The immune response of these preschool children was analyzed.Logistic regression was used to analyze the influencing factors of no(weak)immune response after hepatitis B vaccination in the preschool children in Yujiang district.Results:651 of 1237 preschool children in Yujiang district had no(weak)immune response after hepatitis B vaccination,accounting for 52.63%,and they were set as the occurrence group.There were 586 respondents,accounting for 47.37%,and they were set as the non-occurrence group.The proportions of older age,father carrying hepatitis B virus(HBV),father with history of vaccine no-or weak-response response,mother with history of vaccine no-or weak-response,and poor nutritional status in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that older age,father carrying HBV,father with history of vaccine no-or weak-response,mother with history of vaccine no-or weak-response,and poor nutritional status were all risk factors for no(weak)immune response after hepatitis B vaccination in the preschool children in Yujiang district(OR>1,P<0.05).Conclusions:Older age,father carrying HBV,father with history of vaccine no-or weak-response,mother with history of vaccine no-or weak-response,poor nutritional status are the risk factors for no(weak)immune response after hepatitis B vaccination in the preschool children in Yujiang district.

Preschool childrenHepatitis BVaccinationImmune responseInfluencing factor

胡惠巧

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鹰潭余江区疾病预防控制中心,江西 鹰潭 335200

学龄前儿童 乙肝 疫苗接种 免疫应答 影响因素

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(18)