Effects of Edaravone combined with Alteplase intravenous thrombolysis in treatment of elderly patients with acute cerebral infarction
Objective:To observe effects of Edaravone combined with Alteplase intravenous thrombolysis in treatmentt of elderly patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 80 patients with ACI admitted to the hospital from August 2022 to August 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Alteplase intravenous thrombolysis,while the study group was treated with Edaravone on the basis of that of the control group.The clinical efficacy,the levels of middle cerebral artery[peak systolic blood flow velocity(Vs),end diastolic blood flow velocity(Vd)and mean blood flow velocity(Vm)],the levels of CXC chemokine ligand 1(CXCL1)and CC chemokine ligand 4(CCL4),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the blood flow velocities of Vs,Vd,Vm and other middle cerebral arteries in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CXCL1 and CCL4 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Edaravone combined with Alteplase intravenous thrombolysis in the elderly patients with ACI can improve the total effective rate of treatment and the levels of middle cerebral artery blood flow velocity,and reduce the levels of CXCL1 and CCL4.Moreover,it is superior to simple Alteplase treatment.
万方数据
维普
