Effects of Acetylcysteine combined with Sulbactam and Cefoperazone sodium in treatment of chronic obstructive pulmonary disease patients with pulmonary infection
Objective:To observe effects of Acetylcysteine combined with Sulbactam and Cefoperazone sodium in treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods:A prospective study was conducted on 80 patients with COPD complicated with pulmonary infection admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Sulbactam and Cefoperazone sodium,while the study group was treated with Acetylcysteine tablets on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)],lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak inspiratory pressure(PIP),minute ventilation(MV)]and blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2),arterial partial pressure of oxygen(PaO2)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.00％(38/40),which was higher than 77.50％(31/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PCT,CRP and IL-6 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC,MV and PIP in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,the and differences were statistically significant(P<0.05).After the treatment,the PaCO2 levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of SaO2 and PaO2 in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Acetylcysteine combined with Sulbactam and Cefoperazone sodium in the treatment of the COPD patients with pulmonary infection can improve the total effective rate of treatment and the levels of lung function indexes,improve the levels of blood gas analysis indexes,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Sulbactam and Cefoperazone sodium treatment.
AcetylcysteineSulbactam and Cefoperazone sodiumChronic obstructive pulmonary diseasePulmonary infectionLung functionBlood gas analysis indexInflammatory factor
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