Effects of Acetylcysteine combined with Budesonide in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease
Objective:To observe effects of Acetylcysteine combined with Budesonide in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A prospective study was conducted on 72 patients with AECOPD admitted to the hospital from October 2021 to September 2023.According to the random number table method,they were divided into control group and study group,36 cases in each group.The control group was treated with Budesonide,while the study group was treated with Acetylcysteine capsules on the basis of that of the control group.The clinical efficacy,the levels of lung function[total lung capacity(TLC),forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow rate(PEF)]and oxidative stress index[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 91.67%(33/36),which was higher than 72.22%(26/36)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TLC,FEV1,FVC and PEF in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of SOD and GSH-Px in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the MDA levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Acetylcysteine combined with Budesonide in the treatment of the AECOPD patients can improve the clinical efficacy,improve the levels of lung function indexes,and reduce the body's oxidative stress response.Moreover,it is superior to simple Budesonide treatment.
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