Effects of Thymosin combined with Cefoperazone sodium and Sulbactam sodium in treatment of chronic obstructive pulmonary disease patients with pulmonary infection
Objective:To observe effects of Thymosin combined with Cefoperazone sodium and Sulbactam sodium in treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods:A prospective study was conducted on 108 patients with COPD complicated with pulmonary infection admitted to the hospital from January 2022 to June 2023.According to the random number table method,they were divided into observation group(n=54)and control group(n=54).The control group was treated with Cefoperazone sodium and Sulbactam sodium for injection,while the observation group was treated with Thymosin for injection on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[transforming growth factor-β(TGF-β),interleukin-6(IL-6),procalcitonin(PCT)]and pulmonary oxygenation function indexes[respiratory rate(RR),alveolar-arterial oxygen partial pressure difference(PA-aO2),oxygenation index(OI)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.74%(49/54),which was higher than 75.93%(41/54)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TGF-β,IL-6 and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of RR and PA-aO2 in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the OI of the two groups was higher than that before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Thymosin combined with Cefoperazone sodium and Sulbactam sodium in the treatment of the COPD patients with pulmonary infection can improve the total effective rate of treatment,improve the levels of pulmonary oxygenation function indexes,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Cefoperazone sodium and Sulbactam sodium treatment.
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