Effects of Viable bifidobacterium quadruple combined with Mezlocillin sodium in treatment of children with infectious diarrhea
Objective:To observe effects of Viable bifidobacterium quadruple combined with Mezlocillin sodium in treatment of children with infectious diarrhea.Methods:The clinical data of 98 children with infectious diarrhea admitted to this hospital from January 2022 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,49 cases in each group.The control group was treated with Mezlocillin sodium,while the observation group was treated with Viable bifidobacterium quadruple on the basis of that of the control group.The clinical efficacy,the symptom improvement time,the nutritional indexes[retinol binding protein(RBP),free fatty acid(FFA)]levels,the intestinal mucosal barrier indexes[D-lactic acid,diamine oxidase(DAO)]levels,the intestinal flora number,the inflammatory factor[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.88%(46/49),which was higher than 77.55%(38/49)of the control group,and the difference was statistically significant(P<0.05).The improvement time of fever,diarrhea,vomiting and abdominal pain in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of RBP and FFA in the observation group were higher than those in the control group,the levels of D-lactic acid and DAO were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the number of Enterobacter and Enterococcus in the observation group was less than that in the control group,the number of Lactobacilli and Bifidobacteria was more than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum IL-6,TNF-α and hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Viable bifidobacterium quadruple combined with Mezlocillin sodium in the treatment of the children with infectious diarrhea can improve the total effective rate and the nutritional index levels,shorten the symptom improvement time,improve the intestinal flora number,and reduce the levels of intestinal mucosal barrier indexes and inflammatory factors.Moreover,it is superior to simple Mezlocillin sodium treatment.
万方数据
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