Effects of laparoscopic pancreaticoduodenectomy in treatment of patients with early pancreatic head cancer
Objective:To observe effects of laparoscopic pancreaticoduodenectomy(LPD)in treatment of patients with early pancreatic head cancer.Methods:A prospective study was conducted on 92 patients with early pancreatic head cancer admitted to this hospital from August 2022 to October 2023.According to the random number table method,they were divided into control group and observation group,46 cases in each group.The control group was treated with open pancreaticoduodenectomy(OPD),while the observation group was treated with LPD.The perioperative related indexes(operation time,intraoperative blood loss,number of lymph node dissection,postoperative exhaust time,ambulation time,hospitalization time and postoperative pain degree)levels,the T cell subpopulation indexes(CD4+,CD8+,CD4+/CD8+)levels before and after the surgery,the R0 resection rate,the half-year recurrence rate,and the incidence of complications were compared between the two groups.Results:There was no significant difference in the number of lymph node dissection between the two groups(P>0.05).The intraoperative blood loss in the observation group was less than that in the control group,the operation time was longer than that in the control group,the postoperative exhaust time,the ambulation time and the hospitalization time were shorter than those in the control group,the visual analogue scale score was lower than that in the control group,and the differences were statistically significant(P<0.05).After the surgery,the levels of CD4+and CD4+/CD8+in the two groups were lower than those before the surgery,but those in the observation group were higher than those in the control group;the levels of CD8+in the two groups were higher than those before the surgery,but that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).There were no significant differences in the R0 resection rate,the half-year recurrence rate and the incidence of complications between the two groups(P>0.05).Conclusions:Compared with traditional OPD,LPD in the treatment of the patients with early pancreatic head cancer can reduce the intraoperative blood loss,shorten the postoperative exhaust time,ambulation time,hospitalization time and reduce the postoperative pain.The number of lymph node dissection,the R0 resection rate,the half-year recurrence rate,and the incidence of complications are comparable to those of OPD,but it may prolong the operation time.
LaparoscopyPancreaticoduodenectomyLaparotomyPancreatic head cancerT cell subpopulation
万方数据
维普
