Effects of Huazhuo Yisui decoction combined with Aspirin in treatment of patients with acute cerebral infarction at stable period
Objective:To observe effects of Huazhuo Yisui decoction combined with Aspirin in treatment of patients with acute cerebral infarction at stable period.Methods:A prospective study was conducted on 88 patients with acute cerebral infarction at stable period admitted to this hospital from January to December 2022.According to the random number table method,they were divided into study group and control group,44 cases in each group.The control group was treated with Aspirin,while the study group was treated with Huazhuo Yisui decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the neurological deficit score[National Institutes of Health stroke scale(NHISS)],the cerebral blood flow perfusion index[maximum(Vmax),minimum(Vmin),mean blood flow(Qmean)of common carotid artery,cerebral vascular peripheral resistance(Rv)]levels,the inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.45%(42/44),which was higher than 81.82%(36/44)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of main and secondary TCM syndromes in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The NHISS scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of Vmax,Vmin and Qmean in the two groups after the treatment were higher than those before the treatment,and those in the study group were higher than those in the control group;the Rv levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of serum CRP,IL-6 and TNF-α in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Huazhuo Yisui decoction combined with Aspirin in the treatment of the patients with acute cerebral infarction at stable period can improve the total effective rate of treatment,improve the levels of cerebral blood flow perfusion indexes,and reduce the nerve injury defect degree scores and the levels of inflammatory factors.Moreover,it is superior to simple Aspirin treatment.
万方数据
维普
