Effects of Naoliqing capsules combined with Valsartan in treatment of elderly patients with hypertension of liver-yang hyperactivity type
Objective:To observe effects of Naoliqing capsules combined with Valsartan in treatment of elderly patients with hypertension of liver-yang hyperactivity type.Methods:A prospective study was conducted on 80 elderly patients with hypertension of liver-yang hyperactivity type admitted to the hospital from January 2021 to August 2023.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was treated with Valsartan orally,while the observation group was treated with Naoliqing capsules on the basis of that of the control group.The clinical efficacy,the levels of blood pressure(diastolic blood pressure,systolic blood pressure),the myocardial remodeling indexes[interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD)],and the serum inflammatory factors[interleukin-1β(IL-1β),high-sensitivity C-reactive protein(hs-CRP),endothelin-1(ET-1)]before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(38/40),which was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of diastolic blood pressure,systolic blood pressure,IVST,LVPWT,LVEDD,IL-1β,hs-CRP and ET-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Naoliqing capsules combined with Valsartan in the treatment of the elderly patients with hypertension of liver-yang hyperactivity type can improve the total effective rate,reduce the levels of blood pressure,myocardial remodeling indexes and inflammatory factors.Moreover,it is superior to simple Valsartan treatment.
万方数据
维普
