Effects of Salviae miltiorrhizae and Ligustrazine hydrochloride combined with Benazepril and Irbesartan in treatment of patients with hypertension and heart failure
Objective:To observe effects of Salviae miltiorrhizae and Ligustrazine hydrochloride combined with Benazepril and Irbesartan in treatment of patients with hypertension and heart failure.Methods:A prospective study was conducted on 110 patients with hypertension and heart failure admitted to this hospital from February 2022 to October 2023.They were divided into control group and observation group according to the random number table method,55 cases in each.The control group was treated with Benazepril combined with Irbesartan,while the study group was treated with Salviae miltiorrhizae and Ligustrazine hydrochloride on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[left ventricular ejection fraction(LVEF)],the blood pressure,the vascular endothelial function indexes[endothelin-1(ET-1),nitric oxide(NO)]levels,the myocardial remodeling indexes[interventricular septal thickness(IVST),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)]and the myocardial injury indexes[homocysteine(Hcy),C-reactive protein(CRP),N-terminal pro-brain natriuretic peptide(NT-proBNP)]before and after the treatment,and the incidence of adverse reactions within 1 month after the treatment were compared between the two groups.Results:The total effective rate of the study group was 94.55%(52/55),which was higher than 81.82%(45/55)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF and NO in the study group were higher than those in the control group,the levels of systolic blood pressure,diastolic blood pressure and ET-1 were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of LVESD,LVEDD,IVST,CRP,Hcy and NT-proBNP in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Salviae miltiorrhizae and Ligustrazine hydrochloride combined with Benazepril and Irbesartan in the treatment of the patients with hypertension and heart failure can improve the total effective rate of treatment and the levels of cardiac function indexes,improve the levels of vascular endothelial function indexes,and reduce the levels of blood pressure,myocardial remodeling indexes and myocardial injury indexes.Moreover,it is superior to Benazepril combined with Irbesartan treatment.
Salviae miltiorrhizae and Ligustrazine hydrochloride injectionBenazeprilIrbesartanHypertension and heart failureVascular endothelial functionBlood pressure
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