Effects of Tongfu Jiedu decoction combined with Ulinastatin in treatment of patients with severe acute pancreatitis
Objective:To observe effects of Tongfu Jiedu decoction combined with Ulinastatin in treatment of patients with severe acute pancreatitis(SAP).Methods:A prospective study was conducted on 78 patients with SAP admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into observation group and control group,39 cases in each group.The control group was treated with Ulinastatin,while the observation group was treated with Tongfu Jiedu decoction on the basis of that of the control group.The clinical efficacy,the clinical symptom improvement time,the hospitalization time,the laboratory indexes[blood amylase(AMS),urine amylase(UAMY),lipase(LPS),superoxide dismutase(SOD)]levels,the inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels,and the pain degree[visual analogue scale(VAS)]scores were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 76.92%(30/39)of the control group,and the difference was statistically significant(P<0.05).The remission time of abdominal pain and distension,the recovery time of bowel sounds,the first defecation time and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of AMS,UAMY and LPS in the observation group were lower than those in the control group,the level of SOD was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the VAS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:Tongfu Jiedu decoction combined with Ulinastatin in the treatment of the SAP patients can improve the total effective rate of treatment,shorten the clinical symptom improvement time and the hospitalization time,improve the levels of laboratory indexes,and reduce the levels of inflammatory factors and the VAS score.Moreover,it is superior to simple Ulinastatin treatment.
Severe acute pancreatitisUlinastatinTongfu Jiedu decoctionClinical symptomLaboratory indexInflammatory factor
万方数据
维普
