Effects of modified Qingyi decoction retention enema combined with Octreotide on acute pancreatitis
Objective:To observe effects of modified Qingyi decoction retention enema combined with Octreotide on acute pancreatitis.Methods:The clinical data of 96 patients with acute pancreatitis admitted to this hospital from June 2022 to October 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,48 cases in each group.The control group was treated with Octreotide acetate injection,while the observation group was treated with modified Qingyi decoction retention enema on the basis of that of the control group.The clinical efficacy,the symptom relief time,the disease severity[modified CT severity index(MCTSI),acute physiology and chronic health evaluation II(APACHE II)]score and the serum inflammatory factors[heparin binding protein(HBP),high mobility group protein B1(HMGB1)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.83%(46/48),which was higher than 83.33%(40/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MCTSI and APACHE II scores as well as the serum HBP and HMGB1 levels in the observation group were lower than those in the control group,the disappearance time of abdominal pain,the disappearance time of abdominal distension and the recovery time of serum amylase were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified Qingyi decoction retention enema combined with Octreotide is effective in the treatment of the patients with acute pancreatitis,which can accelerate the symptom relief,reduce the MCTSI and APACHE II scores and the serum HBP and HMGB1 levels.Moreover,it is superior to simple Octreotide treatment.
Acute pancreatitisQingyi decoctionOctreotideRetention enemaHeparin binding proteinHigh mobility group protein B1
万方数据
维普
