Application effects of high-flow nasal cannula oxygen therapy in sequential weaning of mechanical ventilation in patients with severe stroke
Objective:To observe application effects of high-flow nasal cannula oxygen therapy(HFNC)in sequential weaning of mechanical ventilation in patients with severe stroke.Methods:A prospective study was conducted on 118 patients with severe stroke undergoing mechanical ventilation admitted to this hospital from May 2021 to May 2023.According to the random number table method,they were divided into control group and observation group,59 cases in each group.The control group was treated with nasal continuous positive airway pressure(NCPAP)after weaning from mechanical ventilation,while the observation group was treated with HFNC.The levels of blood gas analysis indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],the neurological deficit score[National Institutes of Health stroke scale(NIHSS)],the respiratory muscle strength(maximum inspiratory pressure,maximum expiratory pressure),the pulmonary function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC)]before and after the treatment,and the incidence of complications were compared between the two groups.Results:After the treatment,the PaO2 levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the PaCO2 levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The NIHSS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of respiratory muscle strength such as maximum inspiratory pressure and maximum expiratory pressure in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of FVC and FEV1 in the two groups were higher than those before the treatment,those in the observation group were higher than that in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of complications in the observation group was 3.39%(2/59),which was lower than 15.25%(9/59)in the control group,and the difference was statistically significant(P<0.05).Conclusions:The HFNC in sequential weaning of mechanical ventilation in the patients with severe stroke can improve the levels of blood gas analysis indexes,reduce the neurological impairment,improve the respiratory muscle strength and the lung function,and reduce the incidence of complications.Moreover,it is superior to NCPAP.
StrokeSevereMechanical ventilationNeurological deficit scoreLung functionRespiratory muscle strengthBlood gas analysis
万方数据
维普
