Effects of Doxofylline combined with Tiotropium bromide powder in treatment of patients with chronic obstructive pulmonary disease
Objective:To observe effects of Doxofylline combined with Tiotropium bromide powder in treatment of patients with chronic obstructive pulmonary disease(COPD).Methods:A prospective study was conducted on 70 patients with COPD admitted to the hospital from February 2022 to February 2024.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with Doxofylline,while the observation group was treated with Tiotropium bromide powder on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF),FEV1/FVC]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.29%(33/35),which was higher than 74.29%(26/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-α and IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of FEV1,FVC,FEV1/FVC and PEF in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Doxofylline combined with Tiotropium bromide powder in the treatment of the COPD patients can improve the clinical efficacy,reduce the body's inflammatory response,and improve the lung function.Moreover,it is superior to simple Doxofylline treatment.
万方数据
维普
