Objective:To observe effects of Ambroxol combined with fiberoptic bronchoscopy suction lavage in treatment of patients with severe pneumonia.Methods:A prospective study was conducted on 92 patients with severe pneumonia admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into study group and control group,46 cases in each group.The control group was treated with fiberoptic bronchoscopy suction lavage,while the study group was treated with Ambroxol on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)]and lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),minute ventilation(MV)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 89.13%(41/46),which was higher than 71.74%(33/46)of the control group,and the difference was statistically significant(P<0.05).The cough time,the antipyretic time and the lung rale disappearance time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PCT,CRP and IL-6 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and MV in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ambroxol combined with fiberoptic bronchoscopy suction lavage in the treatment of the patients with severe pneumonia can improve the total effective rate of treatment and the levels of lung function indexes,shorten the disappearance time of clinical symptoms,and reduce the levels of inflammatory factors.Moreover,it is superior to simple fiberoptic bronchoscopy suction lavage treatment.
维普
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