Effects of Shenkang injection combined with Alprostadil injection in treatment of patients with chronic renal failure
Objective:To observe effects of Shenkang injection combined with Alprostadil injection in treatment of patients with chronic renal failure.Methods:A prospective study was conducted on 156 patients with chronic renal failure admitted to this hospital from August 2020 to August 2023.According to the random number table method,they were divided into study group and control group,78 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Alprostadil injection,while the study group was treated with Shenkang injection on the basis of that of the control group.Both groups were treated for 28 d.The clinical efficacy,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)],renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN),24 h urine protein quantification(24hUP)]and renal fibrosis indexes[type IV collagen protein(IV-C),laminin(LN),hyaluronic acid(HA),transforming growth factor-β1(TGF-β1)]before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.59%(73/78),which was higher than 83.33%(65/78)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-1β and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Scr,BUN and 24hUP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IV-C,LN,HA and TGF-β1 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Shenkang injection combined with Alprostadil injection in the treatment of the patients with chronic renal failure can improve the total effective rate of treatment and reduce the levels of inflammatory factors,renal function indexes and renal fibrosis indexes.Moreover,it is superior to simple Alprostadil injection treatment.
万方数据
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