Effects of Fuzheng Jiedu decoction combined with Interferon in treatment of patients with cervical HPV infection
Objective:To observe effects of Fuzheng Jiedu decoction combined with Interferon in treatment of patients with cervical human papillomavirus(HPV)infection.Methods:A prospective study was conducted on 90 patients with cervical HPV infection admitted to this hospital from July 2021 to October 2023.According to the random number table method,they were divided into study group and control group,45 cases in each group.The control group was treated with Interferon,while the study group was treated with Fuzheng Jiedu decoction on the basis of that of the control group.The clinical efficacy,the HPV negative conversion rate,the T cell subsets indexes(CD3+,CD4+,CD8+)levels,the inflammatory indexes[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)]levels,and the TCM syndrome scores before and after the treatment were compared between the two groups.Results:The total effective rate of the study group was 88.89%(40/45),which was higher than 71.11%(32/45)of the control group;the negative conversion rate of HPV in the study group was 93.33%(42/45),which was higher than 77.78%(35/45)in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3+and CD4+in the study group were higher than those in the control group,the level of CD8+was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,PCT and CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the scores of TCM syndromes such as vaginal discharge,lumbosacral pain and vulva pruritus in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Fuzheng Jiedu decoction combined with Interferon in the treatment of the patients with cervical HPV infection can improve the total effective rate of treatment and the HPV negative conversion rate,improve the levels of T cell subsets,reduce the levels of inflammatory indicators and the TCM syndrome scores.Moreover,it is superior to simple Interferon treatment.
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