Comparison of effects of Ibandronate sodium and Zoledronic acid in treatment of patients with malignant tumor bone metastasis
Objective:To compare effects of Ibandronate sodium and Zoledronic acid in treatment of patients with malignant tumor bone metastasis.Methods:A prospective study was conducted on 104 patients with malignant tumor bone metastasis admitted to this hospital from 2022 to 2023.According to the random number table method,they were divided into control group and study group,52 cases in each group.The control group was treated with Zoledronic acid injection,while the study group was treated with Ibandronate sodium injection.The effects of bone metastasis clearance,the degree of cancer pain[numerical rating scale(NRS)]score before and after the treatment,the incidence of skeletal-related events(SREs),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of bone metastasis in the study group was 86.54%(45/52),which was higher than 67.31%(35/52)in the control group,and the difference was statistically significant(P<0.05).After 12 and 24 weeks of treatment,the NRS scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of SREs in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ibandronate sodium in the treatment of the patients with malignant tumor bone metastasis can improve the effects of bone metastasis clearance,and reduce the degree of cancer pain scores and the incidence of SREs.Moreover,it is superior to simple Zoledronic acid injection treatment.
Ibandronate sodiumZoledronic acidMalignant tumor bone metastasisBone metastasis clearanceDegree of cancer painBone-related eventAdverse reaction
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