Effects of different doses of low molecular weight Heparin calcium in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure
Objective:To observe effects of different doses of low molecular weight Heparin calcium in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods:The clinical data of 174 patients with AECOPD complicated with respiratory failure admitted to the hospital from April 2021 to October 2023 were retrospectively analyzed.According to the different doses of low molecular weight Heparin calcium,they were divided into low-dose group(5000AXa U/time,1 time/d,56 cases),medium-dose group(5000AXa U/time,2 times/d,58 cases)and high-dose group(5000AXa U/time,3 times/d,60 cases).The three groups were treated with low molecular weight Heparin calcium for 7 days.The levels of lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],coagulation function indexes[fibrinogen(FIB),activated partial thromboplastin time(APTT),prothrombin time(PT)]and oxygen metabolism indexes[maximum oxygen consumption(VO2max),oxygen uptake rate(O2ER),mixed venous oxygen saturation(SvO2)]before and after the treatment,and the incidence of adverse reactions were compared among the three groups.Results:After the treatment,the levels of FVC,FEV1 and FEV1/FVC in the three groups were higher than those before the treatment,those in the medium and high-dose groups were higher than those in the low-dose group,and the differences were statistically significant(P<0.05);however,there was no statistically significant difference between the medium and high-dose groups(P>0.05).After the treatment,the levels of APTT and PT in the three groups were longer than those before the treatment,and those in the medium and high-dose groups were longer than those in the low-dose group;the FIB levels in the three groups were lower than those before the treatment,and those in the medium and high-dose groups were lower than those in the low-dose group;and the differences were statistically significant(P<0.05).After the treatment,the levels of VO2max,O2ER and SvO2 in the three groups were higher than those before the treatment,those in the medium and high-dose groups were higher than those in the low-dose group,and the differences were statistically significant(P<0.05);however,there was no statistically significant difference between the medium and high-dose groups(P>0.05).The incidence of adverse reactions in the high-dose group was higher than that in the medium and low-dose groups,and the difference was statistically significant(P<0.05).Conclusions:The medium and high doses of low molecular weight Heparin calcium in the treatment of the AECOPD patients with respiratory failure can improve the levels of lung function indexes and oxygen metabolism indexes,and improve the levels of coagulation function indexes.They are superior to low-dose low molecular-weight Heparin calcium treatment,but the incidence of adverse reactions of high-dose low molecular-weight Heparin calcium is higher than that of medium and low-dose low molecular-weight Heparin calcium.
万方数据
维普
