Effects of Vitamin C combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia
Objective:To observe effects of Vitamin C combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:A prospective study was conducted on 98 children with MPP admitted to this hospital from October 2021 to October 2023.According to the random number table method,they were divided into control group and observation group,49 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with Vitamin C on the basis of that of the control group.The disappearance time of clinical symptoms(fever,cough,lung dry and wet rales),the hospitalization time,the levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)]and T cell subsets(CD4+,CD8+,CD4+/CD8+)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.88%(46/49),which was higher than 79.59%(39/49)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,cough,lung dry and wet rales and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,CRP and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD4+and CD4+/CD8+in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of CD8+in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Vitamin C combined with Azithromycin in the treatment of the children with MPP can improve the total effective rate of treatment,shorten the disappearance time of clinical symptoms and the hospitalization time,improve the levels of T cell subsets,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Azithromycin treatment.
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