Effects of endoscopic mucosal dissection in treatment of patients with early gastric cancer of undifferentiated type
Objective:To observe effects of endoscopic mucosal dissection(ESD)in treatment of patients with early gastric cancer of undifferentiated type.Methods:The clinical data of 100 patients with early gastric cancer of undifferentiated type admitted to this hospital from January 2021 to January 2022 were retrospectively analyzed.According to different surgical methods,they were divided into control group and observation group,50 cases in each group.The control group was treated with laparoscopic radical gastrectomy,while the observation group was treated with ESD.The en bloc resection rate and the curative resection rate,the prognostic indicators(hospitalization time,anal exhaust time,first feeding time)levels,the tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125)]levels before and after the surgery,the incidence of complications,and the 1-year recurrence rate were compared between the two groups.Results:The en bloc resection rate of the observation group was higher than that of the control group,the curative resection rate was lower than that of the control group,and the differences were statistically significant(P<0.05).The hospitalization time,the anal exhaust time and the first eating time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).1 week after the surgery,the levels of CEA,CA19-9 and CA125 in the two groups were lower than those before the surgery,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was 12.00%(6/50),which was lower than 36.00%(18/50)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the 1-year recurrence rate between the two groups(P>0.05).Conclusions:ESD treatment for the patients with early gastric cancer of undifferentiated type can improve the en bloc resection rate,and reduce the levels of prognostic indicators,tumor markers and the incidence of complications.It is superior to laparoscopic radical gastrectomy,but the curative resection rate is low.