Effects of Levonorgestrel-releasing intrauterine system combined with Dydrogesterone in treatment of patients with abnormal uterine bleeding after hysteroscopy
Objective:To observe effects of Levonorgestrel-releasing intrauterine system combined with Dydrogesterone in treatment of patients with abnormal uterine bleeding after hysteroscopy.Methods:86 patients with abnormal uterine bleeding after hysteroscopy in this hospital from May 2021 to April 2023 were selected for the prospective study.According to the random number table method,they were divided into study group and control group,43 cases in each group.The control group was treated with Dydrogesterone after the surgery,while the study group was treated with Levonorgestrel-releasing intrauterine system on the basis of that of the control group.Both groups were treated for 3 menstrual cycles.The clinical efficacy,the endometrial thickness,the menstrual volume[pictorial blood loss assessment chart(PBAC)]score,the endometrial basilar artery blood flow parameters[resistance index(RI),pulsatility index(PI)]levels,the serological indicators[vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125)]levels before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.02%(40/43),which was higher than 76.74%(33/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the endometrial thickness of the study group was smaller than that of the control group,the PBAC score was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of RI and PI of endometrial basilar artery in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of VEGF and CA125 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Levonorgestrel-releasing intrauterine system combined with Dydrogesterone in the treatment of the patients with abnormal uterine bleeding after hysteroscopy can improve the total effective rate of treatment,reduce the endometrial thickness,and reduce the PBAC scores and the levels of endometrial basilar artery blood flow parameters and serological indicators.Moreover,it is superior to simple Dydrogesterone treatment.
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