Effects of TAC neoadjuvant chemotherapy combined with breast-conserving surgery in treatment of stage II breast cancer
Objective:To analyze effects of TAC neoadjuvant chemotherapy combined with breast-conserving surgery in treatment of stage II breast cancer.Methods:A prospective study was conducted on 80 patients with stage II breast cancer admitted to the hospital from February 2020 to February 2022.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with breast-conserving surgery,while the study group was treated with TAC neoadjuvant chemotherapy combined with breast-conserving surgery.The success rate of breast-conserving,the levels of tumor markers[serum vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),carbohydrate antigen 15-3(CA15-3),carcinoembryonic antigen(CEA)],the health status[Karnofsky performance status(KPS)]score,the quality of life[functional assessment of cancer therapy-breast(FACT-B)]score,and the incidence of complications at 14 days after the surgery were compared between the two groups before and after the treatment.Results:The success rate of breast-conserving in the study group was 92.50%(37/40),which was higher than 75.00%(30/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CEA,VEGF,CA125 and CA15-3 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the KPS and FACT-B scores of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:TAC neoadjuvant chemotherapy combined with breast-conserving surgery in the treatment of the stage II breast cancer patients can improve the success rate of breast-conserving surgery,the KPS scores and the FACT-B scores,and reduce the levels of tumor markers.Moreover,it is superior to simple breast-conserving surgery.
Stage II breast cancerNeoadjuvant chemotherapyTAC regimenBreast-conserving surgeryTumor markerQuality of lifeHealth status
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