Effects of Glucosamine capsules combined with intra-articular injection of Sodium hyaluronate in treatment of patients with knee osteoarthritis
Objective:To observe effects of Glucosamine capsules combined with intra-articular injection of Sodium hyaluronate in treatment of patients with knee osteoarthritis(KOA).Methods:A prospective study was conducted on 80 patients with KOA admitted to the hospital from March 2020 to March 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with intra-articular injection of Sodium hyaluronate,while the study group was treated with Glucosamine capsules.The clinical efficacy,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-1β]and pain mediators[substance P(SP),prostaglandin E2(PGE2),5-hydroxytryptamine(5-HT),dopamine(DA)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.00%(38/40),which was higher than 77.50%(31/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-6 and IL-1β in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of SP,PGE2,5-HT and DA in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Glucosamine capsules combined with intra-articular injection of Sodium hyaluronate in the treatment of the KOA patients can improve the clinical efficacy and reduce the levels of inflammatory factors and pain mediators.Moreover,it is superior to simple Sodium hyaluronate treatment.
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