Effects of Jiawei Xiaoyao powder combined with Lithium carbonate in treatment of patients with bipolar disorder depressive episodes
Objective:To observe effects of Jiawei Xiaoyao powder combined with Lithium carbonate in treatment of patients with bipolar disorder(BD)depressive episodes.Methods:A prospective study was conducted on 124 patients with BD depressive episodes admitted to Yugan County Psychiatric Hospital from December 2021 to December 2023.According to the random number table method,they were divided into study group and control group,62 cases in each group.The control group was treated with Lithium carbonate tablets,while the study group was treated with Jiawei Xiaoyao powder on the basis of that of the control group.The Hamilton depression scale(HAMD)score,the positive and negative emotion symptom scale(PANAS)score,the Berkeley emotional questionnaire(BEQ)score,the serum oxidative stress indexes[catalase(CAT),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]levels,the serum inflammatory factors[interleukin-6(IL-6),macrophage migration inhibitory factor(MIF),interleukin-1β(IL-1β)]levels,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the PANAS positive emotion score and the BEQ score and the levels of serum CAT,GSH-Px and SOD in the study group were higher than those in the control group;the HAMD score,the PANAS negative emotion score and the levels of serum inflammatory factors such as IL-6,IL-1β and MIF in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Jiawei Xiaoyao powder combined with Lithium carbonate can improve the PANAS positive emotion scores and the BEQ scores,improve the oxidative stress index levels,and reduce the HAMD scores,the PANAS negative emotion scores and the serum inflammatory factor levels in the patients with BD depressive episodes.Moreover,it is superior to simple Lithium carbonate treatment.
万方数据
维普
