Efficiency of combined detection of serum AFP,NSE and CA72-4 levels in staging diagnosis of non-small cell lung cancer
Objective:To investigate efficiency of serum alpha-fetoprotein(AFP),neuron specific enolase(NSE)and carbohydrate antigen 72-4(CA72-4)in staging diagnosis of non-small cell lung cancer(NSCLC).Methods:The clinical data of 80 patients with NSCLC admitted to this hospital from June 2021 to October 2023 were retrospectively analyzed and they set as the lung cancer group.According to the results of pathological examination,they were divided into early and advanced stage.A total of 20 patients with benign pulmonary lesions were selected as the benign group.A total of 50 healthy subjects in the same period were selected as the control group.The levels of serum AFP,NSE and CA72-4 were compared among the three groups and the NSCLC patients with different stages.The receiver operating characteristic(ROC)curve was used to analyze the efficiencies of single and combined detection in the staging diagnosis of NSCLC.Results:The comparison of the levels of serum AFP,NSE and CA72-4 among the three groups showed,lung cancer group>benign group>control group,and the differences were statistically significant(P<0.05).The levels of serum AFP,NSE and CA72-4 in the patients with early stage NSCLC were lower than those in the patients with advanced stage NSCLC,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of serum AFP,NSE and CA72-4 levels in the diagnosis of early stage NSCLC were 0.816,0.807,0.832 and 0.912,respectively;and the diagnostic efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of serum AFP,NSE and CA72-4 levels in the diagnosis of early NSCLC is higher than that of single detection of the three.
Non-small cell lung cancerEarlyAlpha-fetoproteinNeuron specific enolaseCarbohydrate antigen 72-4DetectionEfficiency
万方数据
维普
