Effects of Paricalcitol injection combined with Cinacalcet hydrochloride tablets in treatment of maintenance hemodialysis patients with secondary hyperparathyroidism
Objective:To observe effects of Paricalcitol injection combined with Cinacalcet hydrochloride tablets in treatment of maintenance hemodialysis (MHD) patients with secondary hyperparathyroidism (SHPT). Methods:A prospective study was conducted on 90 MHD patients with SHPT admitted to the hospital from January 2022 to January 2023. According to the random number table method,they were divided into study group and control group,45 cases in each group. The control group was treated with Cinacalcet hydrochloride tablets,while the study group was treated with Paricalcitol injection on the basis of that of the control group. The clinical efficacy,the serum phosphorus level,the serum fibroblast growth factor 23 (FGF23) level,the serum intact parathyroid hormone (iPTH) level,the parathyroid volume,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the study group was 93.33％,which was significantly higher than 77.78％ of the control group,and the difference was statistically significant (P<0.05). After the treatment,the levels of serum phosphorus,serum FGF23,serum iPTH in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and parathyroid volume in the two groups were smaller than those before the treatment,those in the study group was smaller than those in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Paricalcitol injection combined with Cinacalcet hydrochloride tablets in the treatment of the MHD patients with SHPT can improve the total effective rate of treatment,and reduce the serum phosphorus,serum FGF23,serum iPTH levels and the parathyroid volume. Moreover,it is superior to simple Cinacalcet hydrochloride tablets treatment.
万方数据
维普
