Effects of Rivaroxaban combined with Alteplase in treatment of patients with acute pulmonary embolism
Objective:To observe effects of Rivaroxaban combined with Alteplase in treatment of patients with acute pulmonary embolism. Methods:The clinical data of 60 patients with acute pulmonary embolism admitted to this hospital from 2020 to 2023 were retrospectively analyzed. According to different treatment methods,they were divided into control group and observation group,30 cases in each group. Both groups received basic treatment. On this basis,the control group was treated with Warfarin combined with Alteplase,while the observation group was treated with Rivaroxaban combined with Alteplase. Both groups were treated for 1 month. The clinical efficacy,the blood gas analysis indexes[arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),pH value]and the coagulation function indexes[fibrinogen (FIB),D-dimer (D-D)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the observation group was 93.33％ (28/30),which was higher than 66.67％ (20/30) of the control group,and the difference was statistically significant (P<0.05). After the treatment,the PaO2 levels and pH values of the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the PaCO2 levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant (P<0.05). After the treatment,the levels of FIB and D-D in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Rivaroxaban combined with Alteplase in the treatment of the patients with acute pulmonary embolism can improve the total effective rate of treatment,improve the levels of blood gas analysis indexes,and reduce the levels of coagulation function indexes. Moreover,it is superior to Warfarin combined with Alteplase treatment.
Acute pulmonary embolismRivaroxabanAlteplaseWarfarinBlood gas analysisCoagulation functionAdverse reaction
万方数据
维普
