Effects of Carboprost tromethamine combined with Carbetocin on prevention of postpartum hemorrhage after cesarean section
Objective:To observe effects of Carboprost tromethamine combined with Carbetocin on prevention of postpartum hemorrhage after cesarean section. Methods:The clinical data of 78 parturients who underwent cesarean section in the hospital from 2020 to 2022 were retrospectively analyzed. According to the different drugs used,they were divided into control group and observation group,39 cases in each. The control group was given Carbetocin to prevent postpartum hemorrhage,while the observation group was combined with Carboprost tromethamine on the basis of that of the control group. The amount of bleeding 2 h after delivery,the hemostatic effect,the coagulation function indexes[thrombin time (TT),fibrinogen (FIB),prothrombin time (PT)]levels before and 24 h after delivery,and the incidence of adverse reactions were compared between the two groups. Results:The amount of bleeding 2 h after delivery in the observation group was less than that in the control group,and the difference was statistically significant (P<0.05). The total effective rate of hemostasis in the observation group was 92.21％ (36/39),which was higher than 74.36％ (29/39) in the control group,and the difference was statistically significant (P<0.05). 24 h after delivery,the TT and PT in the two groups were shorter than those before delivery,and those in the observation group were shorter than those in the control group;the FIB levels in the two groups were higher than those before delivery,and that in the observation group was higher than that in the control group;and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Carboprost tromethamine combined with Carbetocin in the prevention of postpartum hemorrhage after cesarean section can effectively reduce the amount of postpartum hemorrhage,improve the hemostatic effects,and improve the levels of coagulation function indexes. Moreover,it is superior to simple Carbetocin treatment.
Cesarean sectionPostpartum hemorrhageCarbetocinCarboprost tromethamineHemostatic effectCoagulation function
万方数据
维普
