Effects of Salvianolic acids for injection combined with conventional Western medicine in treatment of patients with transient ischemic attack
Objective:To observe effects of Salvianolic acids for injection combined with conventional Western medicine in treatment of patients with transient ischemic attack (TIA). Methods:The clinical data of 112 patients with TIA admitted to this hospital from January to December 2022 were retrospectively analyzed. According to different treatment methods,they were divided into study group and control group,56 cases in each group. Both groups received basic treatment. On this basis,the control group was treated with conventional Western medicine (Aspirin+Clopidogrel),while the study group was treated with Salvianolic acid for injection on the basis of that of the control group. Both groups were treated for 2 weeks. The clinical efficacy,the cerebral artery peak velocity,the platelet-related factors[thromboxane B2 (TXB2),cyclic adenosine monophosphate (cAMP)]levels before and after the treatment,the incidence of cerebral infarction at 6 months after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the study group was 94.64％ (53/56),which was higher than 82.14％ (46/56) of the control group,and the difference was statistically significant (P<0.05). After the treatment,the peak flow velocity of anterior cerebral artery,middle cerebral artery and posterior cerebral artery in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05). After the treatment,the levels of TXB2 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of cAMP in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant (P<0.05). The incidence of cerebral infarction in the study group was lower than that in the control group,the difference was statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Salvianolic acid for injection combined with conventional Western medicine in the treatment of the TIA patients can improve the total effective rate of treatment and the cerebral artery peak velocities,improve the levels of platelet-related factors,and reduce the incidence of cerebral infarction. Moreover,it is superior to simple conventional Western medicine treatment.
Transient ischemic attackSalvianolic acid for injectionAspirinClopidogrelCerebral artery peak velocityPlatelet related factorCerebral infarction
万方数据
维普
