Effects of Huoxin pills combined with conventional Western medicine in treatment of patients with coronary heart disease angina pectoris
Objective:To observe effects of Huoxin pills combined with conventional Western medicine in treatment of patients with coronary heart disease angina pectoris. Methods:A prospective study was conducted on 70 patients with coronary heart disease angina pectoris admitted to this hospital from December 2022 to December 2023. According to the random number table method,they were divided into study group and control group,35 cases in each group. The control group was treated with conventional Western medicine,while the study group was treated with Huoxin pills on the basis of that of the control group. The clinical efficacy,the cardiac function indexes[left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter (LVESD),left ventricular ejection fraction (LVEF)]levels,the vascular endothelial function indexes[endothelin-1 (ET-1),nitric oxide (NO)]levels,the myocardial injury markers[matrix metalloproteinase-9 (MMP-9),soluble intercellular adhesion molecule-1 (sICAM-1)]levels,the clinical symptoms (duration of angina pectoris,number of angina pectoris attacks),and the TCM syndrome score before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the study group was 91.43％ (32/35),which was higher than 68.57％ (24/35) of the control group,and the difference was statistically significant (P<0.05). The levels of LVESD and LVEDD in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant (P<0.05). The levels of ET-1 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the NO levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant (P<0.05). The levels of MMP-9 and sICAM-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). The duration of angina pectoris in the two groups was shorter than that before the treatment,and that in the study group was shorter than that in the control group;the number of angina pectoris attacks in the two groups was less than that before the treatment,and that in the study group was less than that in the control group;and the differences were statistically significant (P<0.05). The scores of TCM syndromes such as facial edema,mental fatigue and shortness of breath,chest tightness and heartache in the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Huoxin pills combined with conventional Western medicine can improve the total effective rate of treatment,improve the levels of cardiac function indexes and vascular endothelial function indexes,relieve the clinical symptoms,reduce the TCM syndrome scores and the levels of myocardial injury markers in the patients with coronary heart disease and angina pectoris. Moreover,it is superior to simple conventional Western medicine treatment.
万方数据
维普
