Effects of Juhong capsules combined with Ambroxol hydrochloride in treatment of acute exacerbation of chronic bronchitis
Objective:To observe effects of Juhong capsules combined with Ambroxol hydrochloride in treatment of acute exacerbation of chronic bronchitis. Methods:A prospective study was conducted on 88 patients with acute exacerbation of chronic bronchitis admitted to Jinping County People's Hospital from February 2022 to February 2024. They were divided into control group and study group by using the random number table method,44 cases in each group. The control group was treated with Ambroxol hydrochloride tablets,while the study group was treated with Juhong capsules on the basis of that of the control group. The clinical efficacy,the disappearance time of clinical symptoms,the blood gas analysis indexes[arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2)]and the pulmonary function indexes[forced expiratory volume in one second (FEV1),FEV1/forced vital capacity (FVC)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the study group was 97.73％ (43/44),which was higher than 81.82％ (36/44) of the control group,and the difference was statistically significant (P<0.05). The disappearance time of wheezing,cough and sputum in the study group was shorter than that in the control group,and the difference was statistically significant (P<0.05). After the treatment,the PaO2 levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the PaCO2 level of the two groups was lower than that before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant (P<0.05). The levels of FEV1 and FEV1/FVC in the two groups were higher than those before the treatment,those in the study group were higher than the those in control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Juhong capsules combined with Ambroxol hydrochloride in the treatment of the patients with acute exacerbation of chronic bronchitis can improve the total effective rate of treatment and the levels of lung function indexes,shorten the disappearance time of clinical symptoms,and improve the levels of blood gas analysis indexes. Moreover,it is superior to simple Ambroxol hydrochloride treatment.
Juhong capsulesAmbroxol hydrochlorideChronic bronchitisAcute attackBlood gas analysisLung functionAdverse reaction
万方数据
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