Effects of Aidi injection combined with TPF chemotherapy in treatment of patients with middle and middle and advanced cervical cancer
Objective:To observe effects of Aidi injection combined with TPF (Cisplatin+Paclitaxel+Fluorouracil) chemotherapy in treatment of patients with middle and advanced cervical cancer. Methods:The clinical data of 68 patients with middle and advanced cervical cancer admitted to this hospital from May 2022 to July 2023 were retrospectively analyzed. According to different treatment methods,they were divided into control group (n=34) and study group (n=34). The control group was treated with TPF chemotherapy,while the study group was treated with Aidi injection on the basis of that of the control group. The disease control rate,the levels of cellular immune function indexes[CD4+/CD8+,CD4+,CD3+,natural killer (NK) cells]and serum tumor markers[carcinoembryonic antigen-related cell adhesion factor 6 (CEACAM6),squamous cell carcinoma antigen (SCCA),tumor specific growth factor (TSGF)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The disease control rate of the study group was 91.18％ (31/34),which was higher than 70.59％ (24/34) of the control group,the difference was statistically significant (P<0.05). After the treatment,the levels of NK cells,CD3+,CD4+and CD4+/CD8+in the two groups were lower than those before the treatment,but those in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05). The levels of CEACAM6,SCCA and TSGF in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions such as thrombocytopenia,nausea/vomiting,liver/kidney function injury,bone marrow suppression between the two groups (P>0.05). Conclusions:Aidi injection combined with TPF chemotherapy in the treatment of the patients with middle and advanced cervical cancer can improve the disease control rate and the cellular immune function index levels,and reduce the levels of tumor markers. Moreover,it is superior to simple TPF chemotherapy.
Aidi injectionTPF chemotherapy regimenMiddle and advancedCervical cancerDisease control rateTumor markerCellular immunity
万方数据
维普
