Efficiency of combined detection of serum PCT,IL-6 and ET-1 levels in diagnosis of respiratory failure secondary to severe pneumonia
Objective:To analyze efficiency of combined detection of serum procalcitonin (PCT),interleukin-6 (IL-6) and endothelin-1 (ET-1) levels in diagnosis of respiratory failure secondary to severe pneumonia. Methods:126 patients with severe pneumonia admitted to the hospital from May 2020 to August 2023 were selected as the study group,and 126 healthy subjects in the hospital during the same period were selected as the control group. The levels of serum PCT,IL-6 and ET-1 were compared between the two groups and among the patients with secondary respiratory failure and without secondary respiratory failure. The receiver operating characteristic curve (ROC) was drawn,and the area under the curve (AUC) was calculated. The efficiencies of single and combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia were analyzed. Results:The levels of serum PCT,IL-6 and ET-1 in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05). The levels of serum PCT,IL-6 and ET-1 in the patients with secondary respiratory failure were higher than those in the patients without secondary respiratory failure,and the differences were statistically significant (P<0.05). ROC curve analysis showed that the AUCs of single and combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia were 0.706,0.659,0.668 and 0.887,separately;the efficiency of the combined detection was higher than that of each single detection. Conclusions:The efficiency of combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia is higher than that of each single detection.
Severe pneumoniaRespiratory failureProcalcitoninInterleukin-6Endothelin-1Diagnosis
万方数据
维普
