Distribution and drug resistance of pathogenic bacteria in sputum culture of ICU patients with different duration of invasive mechanical ventilation
Objective:To analyze distribution and drug resistance of pathogenic bacteria in sputum culture of patients with different duration of invasive mechanical ventilation in intensive care unit (ICU). Methods:The clinical data of 100 patients with invasive mechanical ventilation admitted to the ICU of the hospital from January 2021 to January 2023 were retrospectively analyzed. According to the duration of invasive mechanical ventilation,they were divided into>7 d group (45 cases) and ≤7 d group (55 cases). The sputum culture and drug sensitivity test were performed in both groups. The distribution and drug resistance of pathogenic bacteria were compared between the two groups. Results:54 strains of pathogenic bacteria were detected in the>7 d group,and 63 strains of pathogenic bacteria were detected in the ≤7 d group. Gram-negative bacteria were the most common pathogens detected in both groups,followed by Gram-positive bacteria. Pseudomonas aeruginosa and Acinetobacter baumannii were the main Gram-negative bacteria in the two groups,and Staphylococcus aureus was the main Gram-positive bacteria. There were no significant differences in the distribution of gram-negative bacteria,gram-positive bacteria and fungi between the two groups (P>0.05). Pseudomonas aeruginosa and Acinetobacter baumannii in the>7 d group had the highest resistance rate to Levofloxacin and the lowest resistance rate to Gentamicin. In the ≤7 d group,the resistance rate of Pseudomonas aeruginosa to Piperacillin,Ceftazidime,Cefepime and Compound sulfamethoxazole was the highest,and the resistance rate to Imipenem,Biapenem and Gentamicin was the lowest. The resistance rate of Acinetobacter baumannii to Levofloxacin was the highest,and the resistance rate to Cefoperazone,Cefepime,Compound sulfamethoxazole and Gentamicin was the lowest. The resistance rate of Pseudomonas aeruginosa to Levofloxacin in the>7 d group was 9/14,which was higher than 4/17 in the ≤7 d group,and the difference was statistically significant. Staphylococcus aureus in both groups had the highest resistance rate to Penicillin,and the lowest resistance rate to Ciprofloxacin and Gentamicin;the resistance rate of Staphylococcus aureus to Levofloxacin in the>7 d group was 6/8,which was higher than 3/14 in the ≤7 d group;and the differences were statistically significant (P<0.05). There were no significant differences in the resistance rates of Pseudomonas aeruginosa and Staphylococcus aureus to other antibiotics and Acinetobacter baumannii to antibiotics between the two groups (P>0.05). Conclusions:Gram-negative bacteria are the most common pathogens detected in the ICU patients with invasive mechanical ventilation duration>7 d and ≤7 d,followed by Gram-positive bacteria. Gram-negative bacteria were mainly Pseudomonas aeruginosa and Acinetobacter baumannii,and Gram-positive bacteria were mainly Staphylococcus aureus. The resistance of pathogens to antibiotics is different.
Invasive mechanical ventilationDifferent durationIntensive care unitSputum culturePathogenic bacteriaDistributionDrug resistance
万方数据
维普
