Objective:To observe effects of Betahistine combined with Flunarizine hydrochloride in treatment of patients with vertebrobasilar insufficiency vertigo (VBIV). Methods:The clinical data of 70 patients with VBIV admitted to this hospital from January 2021 to June 2023 were retrospectively analyzed. According to different treatment regimens,they were divided into control group and observation group,35 cases in each group. The control group was treated with Flunarizine hydrochloride,while the observation group was treated with Betahistine on the basis of that of the control group. The levels of cerebral hemodynamic indexes[left vertebral artery (LVA),right vertebral artery (RVA),mean blood flow velocity of basilar artery (BA)]and hemorheology indexes[high shear whole blood viscosity (HWBV),plasma viscosity (PV),low shear whole blood viscosity (LWBV)],the vertigo degree[dizziness handicap inventory (DHI)],the coagulation function indexes[prothrombin time (PT),activated partial thromboplastin time (APTT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:After the treatment,the mean blood flow velocities of LVA,RVA and BA in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05). The levels of HWBV,PV and LWBV in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05). The DHI scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05). The levels of PT and APTT in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Betahistine combined with Flunarizine hydrochloride in the treatment of the VBIV patients can improve the levels of cerebral hemodynamics and coagulation function,and reduce the levels of hemorheology indexes and the DHI scores. Moreover,it is superior to simple Flunarizine hydrochloride treatment.
维普
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