Effects of Octreotide combined with conventional drugs in treatment of patients with acute upper gastrointestinal bleeding
Objective:To observe effects of Octreotide combined with conventional drugs in treatment of patients with acute upper gastrointestinal bleeding. Methods:The clinical data of 316 patients with acute upper gastrointestinal bleeding admitted to this hospital from May 2021 to July 2022 were retrospectively analyzed. According to different treatment methods,they were divided into control group and study group,158 cases in each. Both groups were given basic treatment. On this basis,the control group was treated with conventional drugs (Thrombin+Omeprazole sodium),while the study group was treated with Octreotide on the basis of that of the control group. The clinical efficacy,the clinical indicators (hemostasis time,abdominal pain disappearance time,fecal occult blood test negative conversion time,hospitalization time) levels,the inflammatory indicators[tumor necrosis factor-α (TNF-α),high-sensitivity C-reactive protein (hs-CRP)]and coagulation function indicators[activated partial thromboplastin time (APTT),prothrombin time (PT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of treatment in the study group was 92.41％ (146/158),which was higher than 74.05％ (117/158) in the control group,and the difference was statistically significant (P<0.05). The hemostasis time,the abdominal pain disappearance time,fecal occult blood test negative conversion time and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant (P<0.05). After the treatment,the levels of TNF-α and hs-CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). After the treatment,the PT and APTT in the two groups were shorter than those before the treatment,those in the study group were shorter than those in the control group,and the differences were statistically significant (P<0.05). However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions:Octreotide combined with conventional drugs in the treatment of the patients with acute upper gastrointestinal bleeding can improve the total effective rate of treatment,improve the levels of clinical indicators and coagulation function indicators,and reduce the levels of inflammatory indicators. Moreover,it is superior to simple conventional drug therapy.
万方数据
维普
