Application effects of thoracic paravertebral block combined with general anesthesia in patients undergoing radical resection of lung cancer
Objective:To observe application effects of thoracic paravertebral block combined with general anesthesia in patients undergoing radical resection of lung cancer. Methods:A prospective study was conducted on 80 patients with radical resection of lung cancer admitted to the hospital from March 2022 to March 2023. According to the random number table method,they were divided into control group and study group,40 cases in each group. The control group was treated with general anesthesia,while the study group was combined with thoracic paravertebral block on the basis of that of the control group. The recovery time,the recovery quality score,the pain degree at different time after the surgery[visual analogue scale (VAS)],the hemodynamic indexes at different time (heart rate,systolic blood pressure),the anesthesia quality (onset time of anesthesia,continuous analgesia time,analgesic drug dosage within 24 h after the surgery),the stress indexes at different time[norepinephrine (NE),cortisol (Cor)],the postoperative comfort[general comfort questionnaire (GCQ)],and the incidence of adverse reactions were compared between the two groups. Results:The recovery time of the study group was shorter than that of the control group,the recovery quality score was higher than that of the control group,and the differences were statistically significant (P<0.05). The VAS scores of the study group 12 and 24 h after the surgery were lower than those of the control group,and the differences were statistically significant (P<0.05). 5 minutes after anesthesia induction and 5 minutes after tracheal intubation,the levels of heart rate and systolic blood pressure in the two groups were lower than those 5 min before anesthesia induction,and the levels of heart rate and systolic blood pressure in the study group were lower than those in the control group 5 minutes after tracheal intubation,and the differences were statistically significant (P<0.05). The onset time of anesthesia in the study group was shorter than that in the control group,the continuous analgesia time was longer than that in the control group,the analgesic drug dosage within 24 h after the surgery was less than that in the control group,and the differences were statistically significant (P<0.05). 24 h after the surgery,the levels of NE and Cor in the two groups were higher than those 15 min before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). 48 h after the surgery,the GCQ scores of the two groups were higher than those 12 h after the surgery,that in the study group was higher than that in the control group,and the differences were statistically significant (P<0.05). Further,the incidence of adverse reactions in the study group was 7.50％ (3/40),which was lower than 25.00％ (10/40) in the control group,and the difference was statistically significant (P<0.05). Conclusions:The thoracic paravertebral block combined with general anesthesia in the patients undergoing radical resection of lung cancer can improve the quality of recovery and anesthesia,stabilize the hemodynamics,improve the postoperative comfort,shorten the recovery time,relieve the pain,and reduce the stress index levels and the incidence of adverse reactions. Moreover,it is superior to simple general anesthesia.
Thoracic paravertebral blockGeneral anesthesiaRadical resection of lung cancerRecovery qualityHemodynamics
万方数据
维普
